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KMID : 0369820100400020079
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Jorunal of Korean Pharmaceutical Sciences
2010 Volume.40 No. 2 p.79 ~ p.84
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Enhanced Iontophoretic Delivery of Risedronate Sodium Across Hairless Mice Skin
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Hwang In-Young
Lee Mi-Jung
Jung Suk-Hyun
Jeong Seo-Young
Cho Sun-Hang
Gil Young-Sig
Jeong Sang-Young
Shin Byung-Cheol
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Abstract
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Osteoporosis was traditionally defined by the occurrence of nontraumatic fractures, especially of the spine, in the setting of low bone mass. Bisphosphonates are an important group of therapeutic agents for the management of osteoporosis, as they inhibit bone resorption and increase bone density, thereby potentially decreasing fracture risk. Risedronate sodium is a bisphosphonate class used by oral formulation. In this study, risedronate was transdermally delivered by iontophoresis. Effects of polarity, pH, current density, and drug concentration were studied using a side-by-side diffusion cell including the hairless mice skin. In addition we studied effect of enhancers. The flux was evaluated by HPLC/UV system. The amount of transported drug under iontophoretic delivery was approximately 186 fold higher than that under passive delivery. Flux was proportional to the increase of drug concentration and current density. The flux was observed about 0.68mg/ when the amout of Propyleneglycol monolaurate (PGML) used 1% as enhancer. Results indicated that iontophoresis is an effective method for transdermal administration of risedronate sodium
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KEYWORD
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Bisphosphonate, Risedronate, Iontophoresis, Transdermal delivery, Osteoporosis
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